abstract：AIMS/HYPOTHESIS:FTO harbours the strongest known obesity-susceptibility locus in Europeans. While there is growing evidence for a role for FTO in obesity risk in Asians, its association with type 2 diabetes, independently of BMI, remains inconsistent. To test whether there is an association of the FTO locus with obesit...

journal_title：Diabetologia

authors： Li H,Kilpeläinen TO,Liu C,Zhu J,Liu Y,Hu C,Yang Z,Zhang W,Bao W,Cha S,Wu Y,Yang T,Sekine A,Choi BY,Yajnik CS,Zhou D,Takeuchi F,Yamamoto K,Chan JC,Mani KR,Been LF,Imamura M,Nakashima E,Lee N,Fujisawa T,Ka

更新日期：2012-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:We sought to evaluate if the cellular localisation and molecular species of diacylglycerol (DAG) were related to insulin sensitivity in human skeletal muscle. METHODS:Healthy sedentary obese controls (Ob; n = 6; mean±SEM age 39.5 ± 2.3 years; mean ± SEM BMI 33.3 ± 1.4 kg/m(2)), individuals with type 2 ...

journal_title：Diabetologia

authors： Bergman BC,Hunerdosse DM,Kerege A,Playdon MC,Perreault L

更新日期：2012-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Pharmacological augmentation of glucagon-like peptide 1 receptor signalling by dipeptidyl peptidase 4 (DPP-4) inhibition reduced intestinal lipoprotein secretion in experimental studies, suggesting that DPP-4 inhibitors may ameliorate dyslipidaemia and thus reduce cardiovascular risk in patients with ty...

journal_title：Diabetologia

authors： Eliasson B,Möller-Goede D,Eeg-Olofsson K,Wilson C,Cederholm J,Fleck P,Diamant M,Taskinen MR,Smith U

更新日期：2012-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Impaired central vision has been shown to predict diabetic peripheral neuropathy (DPN). Several studies have demonstrated diffuse retinal neurodegenerative changes in diabetic patients prior to retinopathy development, raising the prospect that non-central vision may also be compromised by primary neura...

journal_title：Diabetologia

authors： Sampson GP,Shahidi AM,Vagenas D,Pritchard N,Edwards K,Russell AW,Malik RA,Efron N

更新日期：2012-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:We aimed to describe the prevalence of retinopathy in an aged cohort of Icelanders with and without diabetes mellitus. METHODS:The study population consisted of 4,994 persons aged ≥ 67 years, who participated in the Age, Gene/Environment Susceptibility-Reykjavik Study (AGES-R). Type 2 diabetes mellitus...

journal_title：Diabetologia

authors： Gunnlaugsdottir E,Halldorsdottir S,Klein R,Eiriksdottir G,Klein BE,Benediktsson R,Harris TB,Launer LJ,Aspelund T,Gudnason V,Cotch MF,Jonasson F

更新日期：2012-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Although maternal hyperglycaemia is associated with increased risk of adverse pregnancy outcome, the mechanisms of postprandial hyperglycaemia during pregnancy are poorly understood. We aimed to describe glucose turnover in pregnant women with type 1 diabetes, according to stage of gestation (early vs l...

journal_title：Diabetologia

authors： Murphy HR,Elleri D,Allen JM,Harris J,Simmons D,Rayman G,Temple RC,Umpleby AM,Dunger DB,Haidar A,Nodale M,Wilinska ME,Hovorka R

更新日期：2012-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Individuals with diabetes have increased mortality rates compared with the general population. In patients with type 2 diabetes depression further contributes to the increased mortality. Depression and mortality rates in patients with type 1 diabetes are an understudied phenomenon. We therefore studied ...

journal_title：Diabetologia

authors： Ahola AJ,Harjutsalo V,Saraheimo M,Forsblom C,Groop PH,FinnDiane Study Group.

更新日期：2012-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Several publications suggest an association between certain types of insulin and cancer, but with conflicting results. We investigated whether insulin glargine (A21Gly,B31Arg,B32Arg human insulin) is associated with an increased risk of cancer in a large population-based cohort study. METHODS:Data for ...

journal_title：Diabetologia

authors： Ruiter R,Visser LE,van Herk-Sukel MP,Coebergh JW,Haak HR,Geelhoed-Duijvestijn PH,Straus SM,Herings RM,Stricker BH

更新日期：2012-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Translation of genetic association signals into molecular mechanisms for diabetes has been slow. The glucokinase regulatory protein (GKRP; gene symbol GCKR) P446L variant, associated with inverse modulation of glucose- and lipid-related traits, has been shown to alter the kinetics of glucokinase (GCK) i...

journal_title：Diabetologia

authors： Rees MG,Wincovitch S,Schultz J,Waterstradt R,Beer NL,Baltrusch S,Collins FS,Gloyn AL

更新日期：2012-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of the study was to identify surface bio-markers and corresponding antibody tools that can be used for the imaging and immunoisolation of the pancreatic beta cell and its progenitors. This may prove essential to obtain therapeutic grade human beta cells via stem cell differentiation. METHODS:Us...

journal_title：Diabetologia

authors： Hald J,Galbo T,Rescan C,Radzikowski L,Sprinkel AE,Heimberg H,Ahnfelt-Rønne J,Jensen J,Scharfmann R,Gradwohl G,Kaestner KH,Stoeckert C Jr,Jensen JN,Madsen OD

更新日期：2012-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:The renal and cardiovascular protective effects of angiotensin receptor blocker (ARB) remain controversial in type 2 diabetic patients treated with a contemporary regimen including an angiotensin converting enzyme inhibitor (ACEI). METHODS:We examined the effects of olmesartan, an ARB, on primary compo...

journal_title：Diabetologia

authors： Imai E,Chan JC,Ito S,Yamasaki T,Kobayashi F,Haneda M,Makino H,ORIENT study investigators.

更新日期：2011-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to examine human enteroviruses (HEVs) and other intestinal viruses derived from children who participated in the Babydiet intervention study and to analyse the findings according to the appearance of islet autoantibodies, dietary intervention, maternal type 1 diabetes and clini...

journal_title：Diabetologia

authors： Simonen-Tikka ML,Pflueger M,Klemola P,Savolainen-Kopra C,Smura T,Hummel S,Kaijalainen S,Nuutila K,Natri O,Roivainen M,Ziegler AG

更新日期：2011-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Evidence suggests that bacterial components in blood could play an early role in events leading to diabetes. To test this hypothesis, we studied the capacity of a broadly specific bacterial marker (16S rDNA) to predict the onset of diabetes and obesity in a general population. METHODS:Data from an Epid...

journal_title：Diabetologia

authors： Amar J,Serino M,Lange C,Chabo C,Iacovoni J,Mondot S,Lepage P,Klopp C,Mariette J,Bouchez O,Perez L,Courtney M,Marre M,Klopp P,Lantieri O,Doré J,Charles M,Balkau B,Burcelin R,D.E.S.I.R. Study Group.

更新日期：2011-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:The mechanisms by which transcription factor 7-like 2 (TCF7L2) regulates the pathways that are important in the pathogenesis of type 2 diabetes are unknown. We therefore examined the role of TCF7L2 in hepatic glucose production (HGP) in vitro and characterised the whole-genome chromatin occupancy of TCF...

journal_title：Diabetologia

authors： Norton L,Fourcaudot M,Abdul-Ghani MA,Winnier D,Mehta FF,Jenkinson CP,Defronzo RA

更新日期：2011-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:A growing body of research suggests that the prevalence of major depressive disorder (MDD) in children and youth with type 1 diabetes mellitus is significantly higher than that of youth without type 1 diabetes and is associated with increased illness severity. The objective of this article is to review ...

journal_title：Diabetologia

authors： Korczak DJ,Pereira S,Koulajian K,Matejcek A,Giacca A

更新日期：2011-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:The abnormal intrauterine milieu of intrauterine growth retardation (IUGR) permanently alters gene expression and function of pancreatic beta cells leading to the development of diabetes in adulthood. Expression of the pancreatic homeobox transcription factor Pdx1 is permanently reduced in IUGR islets s...

journal_title：Diabetologia

authors： Pinney SE,Jaeckle Santos LJ,Han Y,Stoffers DA,Simmons RA

更新日期：2011-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type 2 diabetes is regarded as inevitably progressive, with irreversible beta cell failure. The hypothesis was tested that both beta cell failure and insulin resistance can be reversed by dietary restriction of energy intake. METHODS:Eleven people with type 2 diabetes (49.5 ± 2.5 years, BMI 33.6 ± 1.2 ...

journal_title：Diabetologia

authors： Lim EL,Hollingsworth KG,Aribisala BS,Chen MJ,Mathers JC,Taylor R

更新日期：2011-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:It is difficult to use HbA(1c) as an indicator of glycaemic control in patients with neonatal diabetes mellitus (NDM) because of high levels of fetal haemoglobin (HbF) remaining in the blood. In this study, glycated albumin (GA), which is not affected by HbF, and HbA(1c) were compared to evaluate whethe...

journal_title：Diabetologia

authors： Suzuki S,Koga M,Amamiya S,Nakao A,Wada K,Okuhara K,Hayano S,Sarhat AR,Takahashi H,Matsuo K,Tanahashi Y,Fujieda K

更新日期：2011-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type 2 diabetes is a major risk factor for CHD. We hypothesised that diabetes genetic susceptibility variants might be associated with increased CHD risk. METHODS:We examined the individual and cumulative effect of 38 common genetic variants previously reported to be associated with type 2 diabetes on ...

journal_title：Diabetologia

authors： Pfister R,Barnes D,Luben RN,Khaw KT,Wareham NJ,Langenberg C

更新日期：2011-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Bariatric surgery consistently induces remission of type 2 diabetes. We tested whether there are diabetes-specific mechanisms in addition to weight loss. METHODS:We studied 25 morbidly obese patients (BMI 51.7 ± 1.5 kg/m(2) [mean ± SEM]), 13 with non-insulin-treated type 2 diabetes (HbA(1c) 7.1 ± 0.5% ...

journal_title：Diabetologia

authors： Camastra S,Gastaldelli A,Mari A,Bonuccelli S,Scartabelli G,Frascerra S,Baldi S,Nannipieri M,Rebelos E,Anselmino M,Muscelli E,Ferrannini E

更新日期：2011-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:The endogenous production of stromal cell-derived factor-1 (SDF-1) in beta cells in transgenic mice attenuates the development of diabetes in response to streptozotocin. Here we propose that beta cell injury induces SDF-1 production, and the SDF-1/chemokine (C-X-C motif) receptor 4 (CXCR4) interaction a...

journal_title：Diabetologia

authors： Liu Z,Stanojevic V,Avadhani S,Yano T,Habener JF

更新日期：2011-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:We conducted genome-wide association studies (GWASs) and expression quantitative trait loci (eQTL) analyses to identify and characterise risk loci for type 2 diabetes in Mexican-Americans from Starr County, TX, USA. METHOD:Using 1.8 million directly interrogated and imputed genotypes in 837 unrelated t...

journal_title：Diabetologia

authors： Below JE,Gamazon ER,Morrison JV,Konkashbaev A,Pluzhnikov A,McKeigue PM,Parra EJ,Elbein SC,Hallman DM,Nicolae DL,Bell GI,Cruz M,Cox NJ,Hanis CL

更新日期：2011-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to demonstrate that hormonal vitamin D (calcitriol) modulates the local pancreatic islet renin-angiotensin system (RAS) whilst improving islet beta cell secretory function. METHODS:Isolated islets cultured ex vivo under high- or low-glucose conditions and treated with or witho...

journal_title：Diabetologia

authors： Cheng Q,Li YC,Boucher BJ,Leung PS

更新日期：2011-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Pregnancies complicated by diabetes have a higher risk of adverse outcomes for mothers and children, including predisposition to disease later in life, e.g. metabolic syndrome and hypertension. We hypothesised that adverse outcomes from diabetic pregnancies may be linked to compromised placental functio...

journal_title：Diabetologia

authors： Salbaum JM,Kruger C,Zhang X,Delahaye NA,Pavlinkova G,Burk DH,Kappen C

更新日期：2011-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:We quantified the effect of ADRA2A (encoding α-2 adrenergic receptor) variants on metabolic traits and type 2 diabetes risk, as reported in four studies. METHODS:Genotype data for ADRA2A single nucleotide polymorphisms (SNPs) rs553668 and rs10885122 were analysed in >17,000 individuals (1,307 type 2 di...

journal_title：Diabetologia

authors： Talmud PJ,Cooper JA,Gaunt T,Holmes MV,Shah S,Palmen J,Drenos F,Shah T,Kumari M,Kivimaki M,Whittaker J,Lawlor DA,Day IN,Hingorani AD,Casas JP,Humphries SE

更新日期：2011-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to investigate whether components of the renin-angiotensin system and semicarbazide-sensitive amine oxidase (SSAO) are associated with the development of pre-eclampsia in women with type 1 diabetes. METHODS:This was an observational study of 107 consecutive pregnant women with...

journal_title：Diabetologia

authors： Ringholm L,Pedersen-Bjergaard U,Thorsteinsson B,Boomsma F,Damm P,Mathiesen ER

更新日期：2011-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:We examined in skeletal muscle (1) whether fatty acid transport protein (FATP) 1 channels long-chain fatty acid (LCFA) to specific metabolic fates in rats; and (2) whether FATP1-mediated increases in LCFA uptake exacerbate the development of diet-induced insulin resistance in mice. We also examined whet...

journal_title：Diabetologia

authors： Holloway GP,Chou CJ,Lally J,Stellingwerff T,Maher AC,Gavrilova O,Haluzik M,Alkhateeb H,Reitman ML,Bonen A

更新日期：2011-06-01 00:00:00

abstract：:Bone remodelling, which maintains bone mass constant during adulthood, is an energy-demanding process. This, together with the observation that the adipocyte-derived hormone leptin is a major inhibitor of bone remodelling, led to the hypothesis that bone cells regulate energy metabolism through an endocrine mechanism....

journal_title：Diabetologia

authors： Ducy P

更新日期：2011-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:We sought to establish if stem cells contained in cord blood cell allografts have the capacity to differentiate into insulin-expressing beta cells in humans. METHODS:We studied pancreases obtained at autopsy from individuals (n = 11) who had prior opposite-sex cord blood transplants to reconstitute hae...

journal_title：Diabetologia

authors： Huang CJ,Butler AE,Moran A,Rao PN,Wagner JE,Blazar BR,Rizza RA,Manivel JC,Butler PC

更新日期：2011-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Several risk stratification systems have been proposed for predicting development of diabetic foot ulcer. However, little has been published that assesses their similarities and disparities, diagnostic accuracy and evidence level. Consequently, we conducted a systematic review of the existing stratifica...

journal_title：Diabetologia

authors： Monteiro-Soares M,Boyko EJ,Ribeiro J,Ribeiro I,Dinis-Ribeiro M

更新日期：2011-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to provide evidence that the anterior chamber of the eye serves as a novel clinical islet implantation site. METHODS:In a preclinical model, allogeneic pancreatic islets were transplanted into the anterior chamber of the eye of a baboon model for diabetes, and metabolic and op...

journal_title：Diabetologia

authors： Perez VL,Caicedo A,Berman DM,Arrieta E,Abdulreda MH,Rodriguez-Diaz R,Pileggi A,Hernandez E,Dubovy SR,Parel JM,Ricordi C,Kenyon NM,Kenyon NS,Berggren PO

更新日期：2011-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Obesity is a major risk factor for type 2 diabetes. Recent genome-wide association (GWA) studies have identified multiple loci robustly associated with BMI and risk of obesity. However, information on their associations with type 2 diabetes is limited. Such information could help increase our understand...

journal_title：Diabetologia

authors： Li S,Zhao JH,Luan J,Langenberg C,Luben RN,Khaw KT,Wareham NJ,Loos RJ

更新日期：2011-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Carbohydrate-free diet prevents hyperglycaemia and beta cell destruction in the New Zealand Obese (NZO) mouse model. Here we have used a sequential dietary regimen to dissociate the effects of obesity and hyperglycaemia on beta cell function and integrity, and to study glucose-induced alterations of key...

journal_title：Diabetologia

authors： Kluth O,Mirhashemi F,Scherneck S,Kaiser D,Kluge R,Neschen S,Joost HG,Schürmann A

更新日期：2011-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:This meta-analysis assessed the pooled effect of each genetic variant reproducibly associated with diabetic nephropathy. METHODS:PubMed, EMBASE and Web of Science were searched for articles assessing the association between genes and diabetic nephropathy. All genetic variants statistically associated w...

journal_title：Diabetologia

authors： Mooyaart AL,Valk EJ,van Es LA,Bruijn JA,de Heer E,Freedman BI,Dekkers OM,Baelde HJ

更新日期：2011-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Non-alcoholic fatty liver disease (NAFLD) is common in type 2 diabetes but it is unknown whether NAFLD is prevalent in European women at risk of type 2 diabetes. We studied the prevalence of, and risk factors for, NAFLD in European women with previous gestational diabetes (GDM) at high risk of type 2 di...

journal_title：Diabetologia

authors： Forbes S,Taylor-Robinson SD,Patel N,Allan P,Walker BR,Johnston DG

更新日期：2011-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Our recent studies suggest that activation of the wingless-type MMTV integration site (WNT) pathway plays pathogenic roles in diabetic retinopathy and age-related macular degeneration. Here we investigated the causative role of oxidative stress in retinal WNT pathway activation in an experimental model ...

journal_title：Diabetologia

authors： Zhou T,Zhou KK,Lee K,Gao G,Lyons TJ,Kowluru R,Ma JX

更新日期：2011-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type 2 diabetes is an established risk factor for cardiovascular disease (CVD). This increased risk may be due in part to the increased levels of inflammatory factors associated with diabetes. Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a risk marker for CVD and has pro-inflammatory effects...

journal_title：Diabetologia

authors： Nelson TL,Kamineni A,Psaty B,Cushman M,Jenny NS,Hokanson J,Furberg C,Mukamal KJ

更新日期：2011-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:In patients with type 1 diabetes, there has been concern about the effects of recurrent hypoglycaemia and chronic hyperglycaemia on cognitive function. Because other biomedical factors may also increase the risk of cognitive decline, this study examined whether macrovascular risk factors (hypertension, ...

journal_title：Diabetologia

authors： Jacobson AM,Ryan CM,Cleary PA,Waberski BH,Weinger K,Musen G,Dahms W,Diabetes Control and Complications Trial\/EDIC Research Group.

更新日期：2011-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:We determined the effects of 6 years of lifestyle intervention in persons with impaired glucose tolerance (IGT) on the development of retinopathy, nephropathy and neuropathy over a 20 year period. METHODS:In 1986, 577 adults with IGT from 33 clinics in Da Qing, China were randomly assigned by clinic to...

journal_title：Diabetologia

authors： Gong Q,Gregg EW,Wang J,An Y,Zhang P,Yang W,Li H,Li H,Jiang Y,Shuai Y,Zhang B,Zhang J,Gerzoff RB,Roglic G,Hu Y,Li G,Bennett PH

更新日期：2011-02-01 00:00:00

abstract：:The International Insulin Foundation (IIF) has developed and validated a needs-assessment instrument called the Rapid Assessment Protocol for Insulin Access (RAPIA) which has been used in seven countries in four continents to analyse the constraints to delivering effective continuing care for people with diabetes. One...

journal_title：Diabetologia

authors： Gill GV,Yudkin JS,Keen H,Beran D

更新日期：2011-01-01 00:00:00